工作经历

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沃特世公司(Waters Corporation)副总裁

Rausch先生为沃特世公司开发了全新的色谱柱分离技术,对产品商业化和技术商业化进行全面的市场开发。负责色谱分离工艺的工业规模化的开发与建立。

1975-1984年
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Biopure公司(Biopure Corporation)创始人、董事长及首席技术官

基于对大量生物分子以前所未有的纯度(超纯)进行纯化,Rausch先生创立了Biopure的主营业务。他为Biopure公司在蛋白质纯化、生物解毒、蛋白质溶液脱氧相关流程的研究、分离工程与制造方面获得了独特的能力。该项技术将中空纤维膜和膜透析技术用于生物流体无菌处理、特种蛋白质化学反应和粒度分级,创造出一种基于纯化血红蛋白的新型生物化合物。 1984-2005年

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Medical Technology AssociateⅡ(MTAⅡ)公司首席执行官

Medical Technology AssociateⅡ(MTAⅡ)于2010年成立于美国,总部位于波士顿,是一家美国创新生物制药研发生产企业。公司高管来自美国原Biopure公司核心团队,包括其创始人兼首席技术官Carl W. Rausch。

MTAⅡ拥有两大专利——血红蛋白类氧治疗剂Oxigain™和生物制品规模化纯化制备平台ALTAPURE™。目前,MTAⅡ正在美国费城建设一个牛源戊二醛聚合血红蛋白供氧剂的制造工厂。预计其动物用产品将在2019年通过美国FDA及欧洲药品管理局(EMA)的上市许可。

目前相关人用产品正在进行临床工作,有望在2020年初获得俄罗斯、欧盟、美国等地上市许可。

2016年,MTAⅡ与润方(北京)生物科技有限公司达成协议提供ALTAPURE™平台技术,协助中国润方生物完成生产、质控等技术转移,实现产品在大中华区的药品注册、生产和市场推广。

2014年至今

代表论著

Gawryl, M. Clark, T., Rausch, C.

Characterization of highly purified polymerized bovine hemoglobin,” Red Cell Substitutes Proceedings, Second International Symposium of Red Cell Substitutes, ed Sekiguchi,S. 1991, Publisher: Kindai Shuppan, Ltd, p28.

Hansell, D, Wolff, D., Kaul, I, Rausch, C, Gawryl, M.

“Integrated efficacy and safety results:  clinical studies of Hemopure (Hemoglobin glutamer-250 [Bovine], HBOC-201), New York State Society of Anesthesiologists, Inc., Post Graduate Assembly, New York, NY, December 14, 2003.

Clark, T.L, Moreira, P.L., Rentko, V.T., Rausch, C.W., Gawryl, M.S.

“Effect of ultrapurified, polymerized hemoglobin based oxygen carrying solution on routine clinical chemistry tests,” Congress Proceedings, VITH Congress of the International Society for Animal Clinical Biochemistry, University of Guelph, Guelph, Ontario, Canada, 1994.

Gawryl, M., Haskell, M., Rausch, C., Thomas, L.

"Assessment of bovine hemoglobin to induce immediate hypersensitivity reactions." Joint meeting of the American Society for Biochemistry and Molecular Biology and the American Association of Immunologists, New Orleans, Louisiana, June 4-7, 1990. FASEB.

Heckendorf, A. H., Ashare, E., Rausch, C.

"Process scale chromatography the new frontier in high-performance liquid chromatography." Leroith, D., Shiloach, J., Leahy, T.J. Purification of Fermentation products: Applications to Large-Scale Processes. American Chemical Society, Washington, D.C. 1985. 91-104.

Rausch, C.W., Heckendorf, A.H.

"High performance liquid chromatography." Comprehensive Biotechnology: The principles, Applications and Regulations of Biotechnology in Industry, Agriculture and Medicine, Murray Moo-Young, Ed. Pergamon Press, New York. 537-555.

Rentko, T.V., Harris, J.E., Resmini, C., Gawryl, M.S., Rausch, C.W.

"Efficacy of an ultra-purified, polymerized hemoglobin based oxygen carrying solution." American College of Veterinary Internal Medicine 10th Annual Veterinary Medicine Forum, May 1992 (in process).

Wong, Bing L., Shen, Yong Q., Rausch, Carl W.

"The emerging importance of biocatalysts in the pharmaceutical process." “Industrial Use of Enzymes: Technical and Economic Barriers,” Wolnak, B., Scher, M., Eds. Bernard Wolnak and Associates, Inc., Chicago, IL 1991. 209-216.

Jacobs, E.E., Perry, M.S., Weston, J.R., Vlahakes, G.J., Armer, L, Moreau, J.P., Rasmini, C, Harris J.E., Rausch C.W.

“Dose related renal effects of intravenous administration of polymerized bovine hemoglobin solution to rats.” Red Cell Substitutes Proceedings, Second International Symposium of Red Cell Substitutes, ed Sekiguchi.

教育经历

(常春藤联盟)麻省理工学院 化学工程硕士

(常春藤联盟)塔弗茨大学 化学工程硕士 医学工程硕士

(常春藤联盟)塔弗茨大学 化学工程学士