Mr. Carl participated in team work as well as led a team independently, he has unique comprehensive view and executive capacity, could combine the planning skills with organization skills(planning, budget, execution and supervision) well to manage, execute efficiently and seize new business opportunity, referring to areas of biological products,diagnostic reagent, scientific reagent and spectrometer applied to experiment and process engineering etc.
Develop new separation technology of chromatographic column, comprehensive market develop on product commercialization and technology commercialization.1975-1981
Mr. Carl is responsible for development and establishment for industry scale of chromatographic separation process.1981-1984
In 1991, he obtained the milestone development fund of 2.5 billion dollars to develop cooperation research from B.Braun and Lilly company. Besides, he participated in military cooperation projects assisted by the US congress and obtained special fund support from the white house and state government.
The veterinary products Oxyglobin taken charge by him has obtained premarket approval by America FDA and EU EMA in 1998 and 1999, it has been sold 300 thousand units(data up to 2010), medicine products for people HBOC-201 has obtained premarket approval by Medicine Quality Control Committee of South Africa in 2000.1984-2005
He developed a platform based on biomolecule purify technology, covered from biomolecule purification of large volume to biomolecule purification(ultrapure) of small volume which could not be obtained previously.2002-2005
He participated to signing of cooperation contracts, outsourced production,clinical development, pharmaceutical market, financial structure and products registration strategy at America, Europe and Asia, took part in development and service of biological products, including R&D, guiding, creation, management and process development.2006-2008
Mr. Carl was European SME supervisor, he took charge of product test and registration in Europe; guided and developed preclinical study and clinical experiment, guided on filing of production documents and registration documents for global registration of medical products at the same time.2008-2014
Responsible for management and consultancy related to project development of biological products, including pilot research, preclinical research, pharmacology and toxicology, develop cooperation and exchange on medicine license of different region with America FDA, Europe EMA, Canada Department of Health and Chinese Food and Drug Administration; develop CRO business at countries and regions like Japan, South Korean, Taiwan, Hong Kong, Australia, Singapore and Cambodia.Since 2014
Characterization of highly purified polymerized bovine hemoglobin,” Red Cell Substitutes Proceedings, Second International Symposium of Red Cell Substitutes, ed Sekiguchi,S. 1991, Publisher: Kindai Shuppan, Ltd, p28.
“Integrated efficacy and safety results: clinical studies of Hemopure (Hemoglobin glutamer-250 [Bovine], HBOC-201), New York State Society of Anesthesiologists, Inc., Post Graduate Assembly, New York, NY, December 14, 2003.
“Effect of ultrapurified, polymerized hemoglobin based oxygen carrying solution on routine clinical chemistry tests,” Congress Proceedings, VITH Congress of the International Society for Animal Clinical Biochemistry, University of Guelph, Guelph, Ontario, Canada, 1994.
"Assessment of bovine hemoglobin to induce immediate hypersensitivity reactions." Joint meeting of the American Society for Biochemistry and Molecular Biology and the American Association of Immunologists, New Orleans, Louisiana, June 4-7, 1990. FASEB.
"Process scale chromatography the new frontier in high-performance liquid chromatography." Leroith, D., Shiloach, J., Leahy, T.J. Purification of Fermentation products: Applications to Large-Scale Processes. American Chemical Society, Washington, D.C. 1985. 91-104.
"High performance liquid chromatography." Comprehensive Biotechnology: The principles, Applications and Regulations of Biotechnology in Industry, Agriculture and Medicine, Murray Moo-Young, Ed. Pergamon Press, New York. 537-555.
"Efficacy of an ultra-purified, polymerized hemoglobin based oxygen carrying solution." American College of Veterinary Internal Medicine 10th Annual Veterinary Medicine Forum, May 1992 (in process).
"The emerging importance of biocatalysts in the pharmaceutical process." “Industrial Use of Enzymes: Technical and Economic Barriers,” Wolnak, B., Scher, M., Eds. Bernard Wolnak and Associates, Inc., Chicago, IL 1991. 209-216.
“Dose related renal effects of intravenous administration of polymerized bovine hemoglobin solution to rats.” Red Cell Substitutes Proceedings, Second International Symposium of Red Cell Substitutes, ed Sekiguchi.
(Ivy league):MIT, master of chemical engineering
(Ivy league):Tufts University, master of chemical science, master of medical engineering
(Ivy league):Tufts University, bachelor of chemical engineering