Pharmacology and Toxicology

1.A comparison of the hemoglobin based oxygen carrier HBOC-201 to other low volume resuscitation fluids in a model of controlled hemorrhagic shock.pdf

2.A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation.pdf

3.A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury.pdf

4.Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease.pdf

5.A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia.pdf

6.Bloodless reperfusion with the oxygen carrier HBOC201 in acute myocardial infarction a novel platform for cardioprotective probes delivery.pdf

7.BOVINE HEMOGLOBIN-BASED OXYGEN-CARRYING SOLUTION (HBOC-201) IMPROVES FLAP SURVIVAL IN A RAT MODEL OF EPIGASTRIC FLAP FAILURE.pdf

8.Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation—Effects on histopathology and o

9.BOVINE POLYMERIZED HEMOGLOBIN VERSUS HEXTEND RESUSCITATION IN A SWINE MODEL OF SEVERE CONTROLLED HEMORRHAGIC SHOCK WITH DELAY TO DEFINITIVE CARE.pdf

10.Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine.pdf

11.EFFECTS OF BOVINE POLYMERIZED HEMOGLOBIN ON COAGULATION IN CONTROLLED HEMORRHAGIC SHOCK IN SWINE.pdf

12.Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care.pdf

13.IMMUNE EFFECTS OF RESUSCITATION WITH HBOC-201, A HEMOGLOBIN-BASED OXYGEN CARRIER, IN SWINE WITH MODERATELY SEVERE HEMORRHAGIC SHOCK FROM CONTROLLED HEMORRHAGE.pdf

14.Influence of the Hemoglobin Solution HBOC-201 on Tissue Oxygenation in the Rat R1H-Tumor.pdf

15.Low-Volume Resuscitation with a Polymerized Bovine Hemoglobin-Based Oxygen-Carrying Solution(HBOC-201).pdf

16.Prehospital HBOC-201 After Traumatic Brain Injury and Hemorrhagic Shock in Swine.pdf

17.Prehospital hemoglobin-based oxygen carrier resuscitation attenuates postinjury acute lung injury.pdf

18.Prolonged Low-Volume Resuscitation with HBOC-201 in a Large-Animal Survival Model of Controlled Hemorrhage.pdf

19.Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care.pdf

20.Resuscitation From Hemorrhagic Shock Comparing Standard Hemoglobin-Based Oxygen Carrier (HBOC)-201 Versus 7.5% Hypertonic HBOC-201.pdf

21.RESUSCITATION FROM HEMORRHAGIC SHOCK WITH HBOC-201 IN THE SETTING OF TRAUMATIC BRAIN INJURY.pdf

22.The Effect of Hemopure® on Coagulation in Clinically Relevant Concentrations.pdf

23.The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome.pdf

24.Vasoactivity of Bovine Polymerized Hemoglobin (HBOC-201) in Swine With Traumatic Hemorrhagic Shock With and Without Brain Injury.pdf

25.Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201.pdf

26.Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells.pdf

Clinical Study

1.A synthetic haemoglobin-based-oxygen-carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma.pdf

2.Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro.pdf

3.Cardioprotection before revascularization in ischemic myocardial injury and the potential role.pdf

4.Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery Results of a randomized, double-blind trial.pdf

5.South Africa clinical experience with Hemopure.pdf

6.The reduction of the allogenic transfusion requirement in aortic surgery with a Hemoglobin- based solution.pdf

7.The Successful Use of Hemoglobin-Based Oxygen Carrier as a Primary Blood Substitute During Abdominal Aneurysm Repair with Large Blood Loss.pdf

8.The Use of Bovine Hemoglobin Glutamer-250 (Hemopure®) in Surgical Patients Results of a Multicenter, Randomized, Single-Blinded Trial.pdf

9.US Navy experience with research on, and development of, hemoglobin-based oxygen carriers.pdf

10.Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis a three-case series.pdf

11.Experience with the use of Hemopure in the care of a massively burned adult.pdf

12.A Safety and Efficacy Evaluation of Hemoglobin-Based Oxygen Carrier HBOC-201 in a Randomized, Multicenter Red Blood Cell Controlled Trial in Noncardiac Surgery Patients.pdf

13.A Safety and Efficacy Evaluation of Hemoglobin-Based Oxygen Carrier HBOC-201 in a Randomized, Multicenter Red Blood Cell Controlled Trial in Noncardiac Surgery Patients.pdf

14.Hemopure A Potential Option for Anemia in Jehovah’s Witnesses.pdf

15.Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results.pdf