Pharmacology and Toxicology

1.A comparison of the hemoglobin based oxygen carrier HBOC-201 to other low volume resuscitation fluids in a model of controlled hemorrhagic shock.pdf

2.A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation.pdf

3.A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury.pdf

4.Acute and long-term effects of modified hemoglobin (HBOC-201) in a rat model of hypertension and chronic kidney disease.pdf

5.A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia.pdf

6.BOVINE HEMOGLOBIN-BASED OXYGEN-CARRYING SOLUTION (HBOC-201) IMPROVES FLAP SURVIVAL IN A RAT MODEL OF EPIGASTRIC FLAP FAILURE.pdf

7.Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation—Effects on histopathology and o

8.BOVINE POLYMERIZED HEMOGLOBIN VERSUS HEXTEND RESUSCITATION IN A SWINE MODEL OF SEVERE CONTROLLED HEMORRHAGIC SHOCK WITH DELAY TO DEFINITIVE CARE.pdf

9.Coagulation patterns following haemoglobin-based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine.pdf

10.EFFECTS OF BOVINE POLYMERIZED HEMOGLOBIN ON COAGULATION IN CONTROLLED HEMORRHAGIC SHOCK IN SWINE.pdf

11.Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care.pdf

12.IMMUNE EFFECTS OF RESUSCITATION WITH HBOC-201, A HEMOGLOBIN-BASED OXYGEN CARRIER, IN SWINE WITH MODERATELY SEVERE HEMORRHAGIC SHOCK FROM CONTROLLED HEMORRHAGE.pdf

13.Influence of the Hemoglobin Solution HBOC-201 on Tissue Oxygenation in the Rat R1H-Tumor.pdf

14.Low-Volume Resuscitation with a Polymerized Bovine Hemoglobin-Based Oxygen-Carrying Solution(HBOC-201).pdf

15.Prehospital HBOC-201 After Traumatic Brain Injury and Hemorrhagic Shock in Swine.pdf

16.Prehospital hemoglobin-based oxygen carrier resuscitation attenuates postinjury acute lung injury.pdf

17.Prolonged Low-Volume Resuscitation with HBOC-201 in a Large-Animal Survival Model of Controlled Hemorrhage.pdf

18.Resuscitation following severe, controlled hemorrhage associated with a 24 h delay to surgical intervention in swine using a hemoglobin based oxygen carrier as an oxygen bridge to definitive care.pdf

19.Resuscitation From Hemorrhagic Shock Comparing Standard Hemoglobin-Based Oxygen Carrier (HBOC)-201 Versus 7.5% Hypertonic HBOC-201.pdf

20.RESUSCITATION FROM HEMORRHAGIC SHOCK WITH HBOC-201 IN THE SETTING OF TRAUMATIC BRAIN INJURY.pdf

21.The Effect of Hemopure® on Coagulation in Clinically Relevant Concentrations.pdf

22.The use of a hemoglobin-based oxygen-carrying solution (HBOC-201) for extracorporeal membrane oxygenation in a porcine model with acute respiratory distress syndrome.pdf

23.Vasoactivity of Bovine Polymerized Hemoglobin (HBOC-201) in Swine With Traumatic Hemorrhagic Shock With and Without Brain Injury.pdf

24.Enhanced central organ oxygenation after application of bovine cell-free hemoglobin HBOC-201.pdf

25.Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells.pdf

Clinical Study

1.A synthetic haemoglobin-based-oxygen-carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma.pdf

2.Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro.pdf

3.Cardioprotection before revascularization in ischemic myocardial injury and the potential role.pdf

4.Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery Results of a randomized, double-blind trial.pdf

5.South Africa clinical experience with Hemopure.pdf

6.The reduction of the allogenic transfusion requirement in aortic surgery with a Hemoglobin- based solution.pdf

7.The Successful Use of Hemoglobin-Based Oxygen Carrier as a Primary Blood Substitute During Abdominal Aneurysm Repair with Large Blood Loss.pdf

8.The Use of Bovine Hemoglobin Glutamer-250 (Hemopure®) in Surgical Patients Results of a Multicenter, Randomized, Single-Blinded Trial.pdf

9.US Navy experience with research on, and development of, hemoglobin-based oxygen carriers.pdf

10.Use of the blood substitute HBOC-201 in critically ill patients during sickle crisis a three-case series.pdf

11.Experience with the use of Hemopure in the care of a massively burned adult.pdf

12.A Safety and Efficacy Evaluation of Hemoglobin-Based Oxygen Carrier HBOC-201 in a Randomized, Multicenter Red Blood Cell Controlled Trial in Noncardiac Surgery Patients.pdf

13.A Safety and Efficacy Evaluation of Hemoglobin-Based Oxygen Carrier HBOC-201 in a Randomized, Multicenter Red Blood Cell Controlled Trial in Noncardiac Surgery Patients.pdf

14.Hemopure A Potential Option for Anemia in Jehovah’s Witnesses.pdf

15.Proof-of-concept trial to evaluate haemoglobin based oxygen therapeutics in elective percutaneous coronary revascularisation. Rationale, protocol design and haemodynamic results.pdf